Serum or plasma for vitamin B12 analysis is typically collected in tubes with a red or gold top, indicating no additive or a clot activator, respectively. Occasionally, a light green-topped tube containing lithium heparin may also be acceptable. The specific tube type may vary slightly based on laboratory requirements, so consulting with the testing facility beforehand is crucial for accurate results. Choosing the correct tube minimizes the risk of sample contamination or interference, which can lead to inaccurate measurements and potentially misdiagnosis.
Correct specimen collection is paramount for reliable diagnostic testing. Using the appropriate tube preserves the integrity of the sample, preventing in vitro changes that could affect the measured vitamin B12 concentration. Accurate measurement of this crucial nutrient is essential for identifying deficiencies, which can manifest as neurological symptoms, anemia, and other health complications. Historically, recognizing the link between collection methods and accurate analysis has contributed significantly to improved diagnosis and patient management.